Article
Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice.
Science advances - 1 Aug 2020
Do-Umehara Hanh Chi, Chen Cong, Zhang Qiao, Misharin Alexander V, Abdala-Valencia Hiam, Casalino-Matsuda S Marina, Reyfman Paul A, Anekalla Kishore R, Gonzalez-Gonzalez Francisco J, Sala Marc A, Peng Chao, Wu Ping, Wong Catherine C L, Kalhan Ravi, Bharat Ankit, Perlman Harris, Ridge Karen M, Sznajder Jacob I, Sporn Peter H S, Chandel Navdeep S, Yu Jindan, Fu Xiangdong, Petrache Irina, Tuder Rubin, Budinger G R Scott, Liu Jing
Abstract excerpt
Cigarette smoking, the leading cause of chronic obstructive pulmonary disease (COPD), has been implicated as a risk factor for severe disease in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we show that mice with lung epithelial cell-specific loss of function of Miz1, which we identified as a negative regulator of nuclear factor κB (NF-κB) signaling, spontaneously...
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