Article

Cryptochrome Loss Drives COPD-like Lung Pathology through Disrupted Alveolar Epithelial Proliferation and Immune Homeostasis

2026-05-21

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by alveolar destruction, impaired epithelial regeneration and chronic inflammation. While circadian disruption has been linked to COPD pathogenesis, the cellular mechanisms remain unclear. Here, we identify the core clock components Cryptochrome 1 and 2 ( Cry1/2 ) as essential regulators of alveolar epithelial cell proliferat...

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Literature Corpus work: 40aaa34e-0fab-5894-a284-f81deeb29a12
DOI: 10.64898/2026.05.19.726266

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