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Article

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?

1 Feb 2002

Abstract excerpt

Hematopoietic stem cells (HSCs) are the earliest cells of the immune system, giving rise to B and T lymphocytes, monocytes, tissue macrophages, and dendritic cells. In animal models, adoptive transfer of HSCs, depending on circumstances, may cause, prevent, or cure autoimmune diseases. Clinical trials have reported early remission of otherwise refractory autoimmune disorders after either autologous or allogeneic...

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PMID: 11806976
DOI: 10.1182/blood.v99.3.768

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