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Article

Stabilization of GroEL minichaperones by core and surface mutations.

Journal of molecular biology - 19 May 2000

Wang Q, Buckle A M, Fersht A R

Abstract excerpt

We report the crystal structures of two hexa-substituted mutants of a GroEL minichaperone that are more stable than wild-type by 7.0 and 6.1 kcal mol(-1). Their structures imply that the increased stability results from multiple factors including improved hydrophobic packing, optimised hydrogen b...

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Identifiers

PMID: 10801358
DOI: 10.1006/jmbi.2000.3716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10801358-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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