Article
Apolipoprotein E genotype and in vivo amyloid burden in middle-aged Hispanics.
Neurology - 13 Oct 2020
Palta Priya, Rippon Brady, Reitz Christiane, He Hengda, Sherwood Greysi, Ceballos Fernando, Teresi Jeanne, Razlighi Qolamreza, Moreno Herman, Brickman Adam M, Luchsinger José A
Abstract excerpt
OBJECTIVE: To examine in vivo amyloid burden in relation to APOEε4 genotype in middle-aged Hispanics. We hypothesize higher amyloid levels among APOE ε4 carriers vs APOE ε4 noncarriers. METHODS: This is a cross-sectional study in a community-based sample of 249 middle-aged Hispanics in New York City who underwent a 3T brain MRI and PET with the amyloid radioligand 18F-florbetaben. APOE genotype was the primary...
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