Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain.

doi:10.1128/JVI.00945-20

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Article

Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain.

Journal of virology - 27 Oct 2020

Gao Rongyuan, Sreenivasan Chithra C, Sheng Zizhang, Hause Ben M, Zhou Bin, Wentworth David E, Clement Travis, Rausch Dana, Brunick Colin, Christopher-Hennings Jane, Wu Hua, Bausch Christoph L, Sullivan Eddie J, Hoppe Adam D, Huber Victor C, Wang Dan, Li Feng

Abstract excerpt

Influenza remains a global health risk and challenge. Currently, neuraminidase (NA) inhibitors are extensively used to treat influenza, but their efficacy is compromised by the emergence of drug-resistant variants. Neutralizing antibodies targeting influenza A virus surface glycoproteins are critical components of influenza therapeutic agents and may provide alternative strategies to the existing countermeasures....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Immune Evasion

Share to Influenza A virus

Share to Influenza A Virus, H1N1 Subtype

Share to Neutralization Tests

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Share to Sequence Analysis, Protein

Source

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Identifiers

PMID: 32847862
DOI: 10.1128/JVI.00945-20
PMCID: PMC7592206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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