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Article

MCC-SP: a powerful integration method for identification of causal pathways from genetic variants to complex disease.

BMC genetics - 26 Aug 2020

Zhu Yuchen, Ji Jiadong, Lin Weiqiang, Li Mingzhuo, Liu Lu, Zhu Huanhuan, Xue Fuzhong, Li Xiujun, Zhou Xiang, Yuan Zhongshang

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have successfully identified genetic susceptible variants for complex diseases. However, the underlying mechanism of such association remains largely unknown. Most disease-associated genetic variants have been shown to reside in noncoding regions, leading to the hypothesis that regulation of gene expression may be the primary biological mechanism. Current methods...

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PMID: 32847502
DOI: 10.1186/s12863-020-00899-3
PMCID: PMC7477886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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