Article
Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae.
Nature communications - 17 Aug 2020
Ma Kevin C, Mortimer Tatum D, Hicks Allison L, Wheeler Nicole E, Sánchez-Busó Leonor, Golparian Daniel, Taiaroa George, Rubin Daniel H F, Wang Yi, Williamson Deborah A, Unemo Magnus, Harris Simon R, Grad Yonatan H
Abstract excerpt
Neisseria gonorrhoeae is an urgent public health threat due to rapidly increasing incidence and antibiotic resistance. In contrast with the trend of increasing resistance, clinical isolates that have reverted to susceptibility regularly appear, prompting questions about which pressures compete with antibiotics to shape gonococcal evolution. Here, we used genome-wide association to identify loss-of-function (LOF)...
Topics
Join the communities discussing this publication.