Effects of extracellular matrix on the malignant phenotype.

Abstract excerpt

Extracellular matrix molecules, including collagen, glycosaminoglycans (usually linked to a protein core as proteoglycan), elastin, and glycoproteins, influence the initiation and maintenance of differentiation of a variety of cell types. These molecules bind to the cell surface at specific sites and nonspecifically by electrostatic forces. Such interactions may alter the cell's response to growth and...

Topics

• Animals
• Cell Differentiation
• Extracellular Matrix
• Humans
• Phenotype
• Tumor Cells, Cultured