Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extracellular matrix proteins influence phenotype and cytokine expression in human breast cancer cell lines.

European cytokine network - 1 Jan 2000

Hirtenlehne Kora, Pec Martina, Kubista Ernst, Singer Christian F

Abstract excerpt

Tumor growth and invasion are not only the result of malignant transformation but are also dependent on environmental influences from surrounding stroma, extracellular matrix (ECM), local cytokines and systemic hormones. We have investigated the influence of ECM components on three human breast cancer cell lines of different malignant potential: MCF-7, T47D and MDA-MB-231 were cultured on collagen I, collagen IV,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cytokines
Share to Extracellular Matrix Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-1

Share to Neoplasm Invasiveness

Share to Transforming Growth Factor beta

Share to Transforming Growth Factor beta1

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12101080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extracellular matrix proteins influence phenotype and cytokine expression in human breast cancer cell lines.PMID 12101080Read ↗

Collagen and fibronectin promote an aggressive cancer phenotype in breast cancer cells but drive autonomous gene expression patterns.Semantic proximity Read ↗

Effects of extracellular matrix on the malignant phenotype.Semantic proximity Read ↗

Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha.Semantic proximity Read ↗

Cytokine modulation of extracellular matrix gene expression: relevance to fibrotic skin diseasesSemantic proximity Read ↗

Carcinoma Cell-Based Extracellular Matrix Modulates Cancer Cell CommunicationSemantic proximity Read ↗

Phenotypical modifications of immune cells are enhanced by extracellular matrix.Semantic proximity Read ↗

Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors.Semantic proximity Read ↗

The critical effects of matrices on cultured carcinoma cells: Human tumor-derived matrix promotes cell invasive propertiesSemantic proximity Read ↗

Phenotypic switch in blood: effects of pro-inflammatory cytokines on breast cancer cell aggregation and adhesion.Semantic proximity Read ↗

Influence of extracellular matrix macromolecules on normal human keratinocyte phenotype and parathyroid hormone-related protein secretion and expression in vitro.Semantic proximity Read ↗

TGF-beta and extracellular matrix related influences on gene expression and phenotype.Semantic proximity Read ↗

Cytokine profile of breast cell lines after different radiation doses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.