Article
Matrix-dependent plasticity of the malignant phenotype of bladder cancer cells.
Anticancer research - 1 Jan 2000
Hurst Robert E, Kyker Kimberly D, Bonner Rebecca B, Bowditch Ron D, Hemstreet George P
Abstract excerpt
The purpose of this study was to investigate the effect of cancer- and normal basement membrane-derived extracellular matrix to modulate the phenotype of bladder cancer cell lines. Five lines, varying in malignancy from papilloma to highly undifferentiated and invasive and immortalized human urothelial cells, were grown on two extracellular matrix preparations, Matrigel and SISgel. Matrigel represents matrix...
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