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Article

Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study.

Thorax - 1 Nov 2020

Milne Stephen, Li Xuan, Hernandez Cordero Ana I, Yang Chen Xi, Cho Michael H, Beaty Terri H, Ruczinski Ingo, Hansel Nadia N, Bossé Yohan, Brandsma Corry-Anke, Sin Don D, Obeidat Maen

Abstract excerpt

BACKGROUND: The anti-inflammatory pneumoprotein club cell secretory protein-16 (CC-16) is associated with the clinical expression of chronic obstructive pulmonary disease (COPD). We aimed to determine if there is a causal effect of serum CC-16 level on the risk of having COPD and/or its progression using Mendelian randomisation (MR) analysis. METHODS: We performed a genome-wide association meta-analysis for serum...

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Identifiers

PMID: 32839289
DOI: 10.1136/thoraxjnl-2019-214487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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