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Article

CC16 drives VLA-2-dependent SPLUNC1 expression

19 Nov 2023

Abstract excerpt

Rationale CC16 (Club Cell Secretory Protein) is a protein produced by club cells and other non-ciliated epithelial cells within the lungs. CC16 has been shown to protect against the development of obstructive lung diseases and attenuate pulmonary pathogen burden. Despite recent advances in understanding CC16 effects in circulation, the biological mechanisms of CC16 in pulmonary epithelial responses have not been...

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PMID: 38053993
DOI: 10.3389/fimmu.2023.1277582

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