Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Donor genetic backgrounds contribute to the functional heterogeneity of stem cells and clinical outcomes

24 Aug 2020

Abstract excerpt

Abstract Stable and sustainable stem cell sources for stem cell-based therapies are scarce and a key bottleneck for clinical applications. The regenerative potential of stem cells is usually attributed to several allogeneic or even autologous donor-related factors. Genetic background and epigenetic variations in different individuals may significantly affect the functional heterogeneity of stem cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Ethics and Regulation
Share to Mesenchymal stem cell research
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32830917
DOI: 10.1002/sctm.20-0155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Donor genetic backgrounds contribute to the functional heterogeneity of stem cells and clinical outcomesPMID 32830917Read ↗

Adding iPSC donor lines does not adequately control for genetic heterogeneitySemantic proximity Read ↗

Genetic variation and hematopoietic stem cell transplantation: expansion of the paradigm.Semantic proximity Read ↗

Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential.Semantic proximity Read ↗

Leveraging the Genetic Diversity of Human Stem Cells in Therapeutic Approaches.Semantic proximity Read ↗

Common genetic variation drives molecular heterogeneity in human iPSCs.Semantic proximity Read ↗

Common genetic variation drives molecular heterogeneity in human IPSCsSemantic proximity Read ↗

iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.Semantic proximity Read ↗

Bridging population and cell: modelling complex diseases with human induced pluripotent stem cells.Semantic proximity Read ↗

Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs.Semantic proximity Read ↗

Greater genetic diversity is needed in human pluripotent stem cell models.Semantic proximity Read ↗

A new NHGRI Sample Repository for Human Genetic Research collection of induced pluripotent stem cell linesSemantic proximity Read ↗

A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.