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Article

Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-kDa Heat-Shock Protein, HspA1A.

International journal of molecular sciences - 20 Aug 2020

Smulders Larissa, Daniels Amanda J, Plescia Caroline B, Berger Devon, Stahelin Robert V, Nikolaidis Nikolas

Abstract excerpt

HspA1A, a molecular chaperone, translocates to the plasma membrane (PM) of stressed and cancer cells. This translocation results in HspA1A's cell-surface presentation, which renders tumors radiation insensitive. To specifically inhibit the lipid-driven HspA1A's PM translocation and devise new therapeutics it is imperative to characterize the unknown HspA1A's lipid-binding regions and determine the relationship...

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Identifiers

PMID: 32825419
DOI: 10.3390/ijms21175995
PMCID: PMC7503672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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