Article

Dynamic Aha1 Co-Chaperone Binding to Human Hsp90

2019-02-14

Abstract excerpt

Hsp90 is an essential chaperone that requires large allosteric changes to determine its ATPase activity and client binding. Because of the inherent low ATPase activity of human Hsp90, the co-chaperone Aha1, which is the only known ATPase stimulator in eukaryotes, is important for regulation of Hsp90’s allosteric timing. Little is known, however, about the structure of the Hsp90/Aha1 full-length complex. Here, we c...

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Literature Corpus work: 98976f8a-1ce2-5be8-98de-bdf71318d12f
DOI: 10.1101/550228

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