Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Propofol Affects Cortico-Hippocampal Interactions via β3 Subunit-Containing GABAA Receptors.

International journal of molecular sciences - 14 Aug 2020

Kreuzer Matthias, Butovas Sergejus, García Paul S, Schneider Gerhard, Schwarz Cornelius, Rudolph Uwe, Antkowiak Bernd, Drexler Berthold

Abstract excerpt

BACKGROUND: General anesthetics depress neuronal activity. The depression and uncoupling of cortico-hippocampal activity may contribute to anesthetic-induced amnesia. However, the molecular targets involved in this process are not fully characterized. GABAA receptors, especially the type with β3 subunits, represent a main molecular target of propofol. We therefore hypothesized that GABAA receptors with β3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hippocampus
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Propofol

Share to Protein Subunits

Share to Receptors, GABA-A

Source

Open in PubMed Open full text

Identifiers

PMID: 32823959
DOI: 10.3390/ijms21165844
PMCID: PMC7461501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Propofol Affects Cortico-Hippocampal Interactions via β3 Subunit-Containing GABAA Receptors.PMID 32823959Read ↗

Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice.Semantic proximity Read ↗

General anaesthesia disrupts complex cortical dynamics in response to intracranial electrical stimulation in ratsSemantic proximity Read ↗

Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptorsSemantic proximity Read ↗

Enhancement of α5-containing γ-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the β3(N265M) mutation.Semantic proximity Read ↗

An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.Semantic proximity Read ↗

Low frequency stimulation decreases seizure activity in a mutation model of epilepsy.Semantic proximity Read ↗

Cortico-thalamic excitatory-inhibitory dynamics generates <i>α</i> -wave transient patterns encoding anesthetic brain statesSemantic proximity Read ↗

Network and synaptic mechanisms underlying high frequency oscillations in the rat and cat olfactory bulb under ketamine-xylazine anesthesiaSemantic proximity Read ↗

GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice.Semantic proximity Read ↗

Tonic inhibition in principal cells of the amygdala: a central role for α3 subunit-containing GABAA receptors.Semantic proximity Read ↗

Abnormal patterns of sleep and waking behaviors are accompanied by increased slow gamma power in an Ank3 mouse model of epilepsy-bipolar disorder comorbiditySemantic proximity Read ↗

Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.