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Article

Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2014

Oda Toshiaki, Chiba Shuhei, Nagai Tomoaki, Mizuno Kensaku

Abstract excerpt

Primary cilia are formed by extending the microtubule-based axoneme from the mother centriole-derived basal body. Recruitment of Tau tubulin kinase-2 (TTBK2) to the mother centriole and subsequent removal of CP110 and its interactor Cep97 are crucial for the initiation of ciliogenesis. We analyzed the roles of two TTBK2-binding proteins, EB1 and Cep164, in centriolar localization of TTBK2. TTBK2 bound EB1 and...

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Share to Centrioles
Share to Cilia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Tubules, Collecting

Share to Microtubule-Associated Proteins

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Source

Identifiers

PMID: 25297623
DOI: 10.1111/gtc.12191

Genes

TTBK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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