Article
The stumpy gene is required for mammalian ciliogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 26 Feb 2008
Town Terrence, Breunig Joshua J, Sarkisian Matthew R, Spilianakis Charalampos, Ayoub Albert E, Liu Xiuxin, Ferrandino Anthony F, Gallagher A Rachel, Li Ming O, Rakic Pasko, Flavell Richard A
Abstract excerpt
Cilia are present on nearly all cell types in mammals and perform remarkably diverse functions. However, the mechanisms underlying ciliogenesis are unclear. Here, we cloned a previously uncharacterized highly conserved gene, stumpy, located on mouse chromosome 7. Stumpy was ubiquitously expressed, and conditional loss in mouse resulted in complete penetrance of perinatal hydrocephalus (HC) and severe polycystic...
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