Article
PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.
Clinical epigenetics - 20 Aug 2020
Cypris Olivia, Eipel Monika, Franzen Julia, Rösseler Corinna, Tharmapalan Vithurithra, Kuo Chao-Chung, Vieri Margherita, Nikolić Miloš, Kirschner Martin, Brümmendorf Tim H, Zenke Martin, Lampert Angelika, Beier Fabian, Wagner Wolfgang
Abstract excerpt
BACKGROUND: Dyskeratosis congenita (DKC) and idiopathic aplastic anemia (AA) are bone marrow failure syndromes that share characteristics of premature aging with severe telomere attrition. Aging is also reflected by DNA methylation changes, which can be utilized to predict donor age. There is evidence that such epigenetic age predictions are accelerated in premature aging syndromes, but it is yet unclear how this...
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