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Article

Epigenetic-aging-signature to determine age in different tissues

26 Oct 2011

Abstract excerpt

All tissues of the organism are affected by aging. This process is associated with epigenetic modifications such as methylation changes at specific cytosine residues in the DNA (CpG sites). Here, we have identified an Epigenetic-Aging-Signature which is applicable for many tissues to predict donor age. DNA-methylation profiles of various cell types were retrieved from public data depositories - all using the...

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PMID: 22067257
DOI: 10.18632/aging.100395

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