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Conditional silencing of topoisomerase I gene of Mycobacterium tuberculosis validates its essentiality for cell survival.

FEMS microbiology letters - 1 Apr 2014

Ahmed Wareed, Menon Shruti, Godbole Adwait Anand, Karthik Pullela V D N B, Nagaraja Valakunja

Abstract excerpt

Topoisomerases are an important class of enzymes for regulating the DNA transaction processes. Mycobacterium tuberculosis (Mtb) is one of the most formidable pathogens also posing serious challenges for therapeutic interventions. The organism contains only one type IA topoisomerase (Rv3646c), offering an opportunity to test its potential as a candidate drug target. To validate the essentiality of M. tuberculosis...

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PMID: 24593153
DOI: 10.1111/1574-6968.12412

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