Article
Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target.
Tuberculosis (Edinburgh, Scotland) - 1 Sept 2015
Ravishankar Sudha, Ambady Anisha, Awasthy Disha, Mudugal Naina Vinay, Menasinakai Sreenivasaiah, Jatheendranath Sandesh, Guptha Supreeth, Sharma Sreevalli, Balakrishnan Gayathri, Nandishaiah Radha, Ramachandran Vasanthi, Eyermann Charles J, Reck Folkert, Rudrapatna Suresh, Sambandamurthy Vasan K, Sharma Umender K
Abstract excerpt
DNA topoisomerases perform the essential function of maintaining DNA topology in prokaryotes. DNA gyrase, an essential enzyme that introduces negative supercoils, is a clinically validated target. However, topoisomerase I (Topo I), an enzyme responsible for DNA relaxation has received less attention as an antibacterial target, probably due to the ambiguity over its essentiality in many organisms. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.