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Article

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy.

Human molecular genetics - 1 Feb 2009

Villalta S Armando, Nguyen Hal X, Deng Bo, Gotoh Tomomi, Tidball James G

Abstract excerpt

Duchenne muscular dystrophy (DMD) is the most common, lethal, muscle-wasting disease of childhood. Previous investigations have shown that muscle macrophages may play an important role in promoting the pathology in the mdx mouse model of DMD. In the present study, we investigate the mechanism through which macrophages promote mdx dystrophy and assess whether the phenotype of the macrophages changes between the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscular Dystrophy, Animal

Share to Muscular Dystrophy, Duchenne

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Source

Open in PubMed Open full text

Identifiers

PMID: 18996917
DOI: 10.1093/hmg/ddn376
PMCID: PMC2638796

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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