Article
Association of serum neurofilament light and disease severity in patients with spinocerebellar ataxia type 3.
Neurology - 1 Dec 2020
Peng Yun, Zhang Youming, Chen Zhao, Peng Huirong, Wan Na, Zhang Jennifer, Tang Jingyi, Wang Puzhi, Xie Yue, Cai Qiyong, Liu Shaohui, Zhang Xuewei, Wang Chunrong, Yuan Hongyu, Li Tianjiao, Wan Linlin, Shi Yuting, Qiu Rong, Klockgether Thomas, Tang Beisha, Liao Weihua, Jiang Hong
Abstract excerpt
OBJECTIVE: To investigate serum neurofilament light protein (sNfL) levels in patients with spinocerebellar ataxia type 3 (SCA3) and to determine whether they are associated with disease severity. METHODS: This cross-sectional study enrolled 185 healthy controls and 235 ATXN3 mutation carriers (17 asymptomatic stage, 20 preclinical stage, and 198 ataxic stage). We measured sNfL levels with the single molecule...
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