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Article

Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes.

Cell metabolism - 6 Jan 2015

Multhaup Michael L, Seldin Marcus M, Jaffe Andrew E, Lei Xia, Kirchner Henriette, Mondal Prosenjit, Li Yuanyuan, Rodriguez Varenka, Drong Alexander, Hussain Mehboob, Lindgren Cecilia, McCarthy Mark, Näslund Erik, Zierath Juleen R, Wong G William, Feinberg Andrew P

Abstract excerpt

Using a functional approach to investigate the epigenetics of type 2 diabetes (T2D), we combine three lines of evidence-diet-induced epigenetic dysregulation in mouse, epigenetic conservation in humans, and T2D clinical risk evidence-to identify genes implicated in T2D pathogenesis through epigen...

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Share to Adipocytes
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Genetic Loci

Share to Glucose Tolerance Test

Share to RNA, Small Interfering

Share to Transcription Factor 7-Like 2 Protein

Source

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Identifiers

PMID: 25565211
DOI: 10.1016/j.cmet.2014.12.014
PMCID: PMC4340475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25565211-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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