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Article

Genetic basis of right and left ventricular heart shape.

Nature communications - 14 Nov 2024

Burns Richard, Young William J, Aung Nay, Lopes Luis R, Elliott Perry M, Syrris Petros, Barriales-Villa Roberto, Sohrabi Catrin, Petersen Steffen E, Ramírez Julia, Young Alistair, Munroe Patricia B

Abstract excerpt

Heart shape captures variation in cardiac structure beyond traditional phenotypes of mass and volume. Although observational studies have demonstrated associations with cardiometabolic risk factors and diseases, its genetic basis is less understood. We utilised cardiovascular magnetic resonance images from 45,683 UK Biobank participants to construct a heart shape atlas from bi-ventricular end-diastolic surface...

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Identifiers

PMID: 39543113
DOI: 10.1038/s41467-024-53594-7
PMCID: PMC11564811

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