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Article

Rapid repair of human disease-specific single-nucleotide variants by One-SHOT genome editing.

Scientific reports - 18 Aug 2020

Yokouchi Yuji, Suzuki Shinichi, Ohtsuki Noriko, Yamamoto Kei, Noguchi Satomi, Soejima Yumi, Goto Mizuki, Ishioka Ken, Nakamura Izumi, Suzuki Satoru, Takenoshita Seiichi, Era Takumi

Abstract excerpt

Many human diseases ranging from cancer to hereditary disorders are caused by single-nucleotide mutations in critical genes. Repairing these mutations would significantly improve the quality of life for patients with hereditary diseases. However, current procedures for repairing deleterious single-nucleotide mutations are not straightforward, requiring multiple steps and taking several months to complete. In the...

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PMID: 32811847
DOI: 10.1038/s41598-020-70401-7
PMCID: PMC7435196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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