Illuminating autoimmune regulators through controlled variation of the mouse genome sequence.

Abstract excerpt

Gene variants in mice that have strong, Mendelian effects on autoimmune susceptibility have been one of the most productive entry points for identifying genes and processes regulating human autoimmunity. With the tools now available to map and identify new mouse Mendelian gene variants, the handful of spontaneous mutations accumulated over several decades have all been identified, and the main bottleneck lies in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autoimmunity
• Share to Breeding
• Share to Genetic Variation