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Article

Model-driven analysis of mutant fitness experiments improves genome-scale metabolic models of Zymomonas mobilis ZM4.

PLoS computational biology - 1 Aug 2020

Ong Wai Kit, Courtney Dylan K, Pan Shu, Andrade Ramon Bonela, Kiley Patricia J, Pfleger Brian F, Reed Jennifer L

Abstract excerpt

Genome-scale metabolic models have been utilized extensively in the study and engineering of the organisms they describe. Here we present the analysis of a published dataset from pooled transposon mutant fitness experiments as an approach for improving the accuracy and gene-reaction associations of a metabolic model for Zymomonas mobilis ZM4, an industrially relevant ethanologenic organism with extremely high...

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PMID: 32804944
DOI: 10.1371/journal.pcbi.1008137
PMCID: PMC7451989

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