Article
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study.
Brain structure & function - 1 Nov 2020
Vilor-Tejedor Natalia, Operto Grégory, Evans Tavia E, Falcon Carles, Crous-Bou Marta, Minguillón Carolina, Cacciaglia Raffaele, Milà-Alomà Marta, Grau-Rivera Oriol, Suárez-Calvet Marc, Garrido-Martín Diego, Morán Sebastián, Esteller Manel, Adams Hieab H, Molinuevo José Luis, Guigó Roderic, Gispert Juan Domingo
Abstract excerpt
BACKGROUND: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association of Val66Met with whole hippocampal volume included patients of a variety of disorders. However, it remains to be elucidated whether there is an impact of BDNF Val66Met polymorphism on the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.