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Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration.

Biochemical and biophysical research communications - 15 Oct 2020

Hirao-Suzuki Masayo, Koga Takayuki, Sakai Genki, Kobayashi Takanobu, Ishii Yuji, Miyazawa Hiroshi, Takiguchi Masufumi, Sugihara Narumi, Toda Akihisa, Ohara Masahiro, Takeda Shuso

Abstract excerpt

The functional role of fatty acid 2-hydroxylase (FA2H) is controversial in the field of cancer biology due to the dual role of FA2H, particularly related to its interaction with triple-negative breast cancer (TNBC). A previous biochemical- and clinical-focused study suggested that FA2H could dampen TNBC aggressiveness. However, another epidemiological study demonstrated that FA2H expression is associated with...

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PMID: 32798015
DOI: 10.1016/j.bbrc.2020.07.043

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