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Article

Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells.

PloS one - 1 Jan 2017

Thirunavukkarasan Madhumathi, Wang Chao, Rao Angad, Hind Tatsuma, Teo Yuan Ru, Siddiquee Abrar Al-Mahmood, Goghari Mohamed Ally Ibrahim, Kumar Alan Prem, Herr Deron R

Abstract excerpt

Short chain fatty acids (2 to 6 carbons in length) are ubiquitous lipids that are present in human plasma at micromolar concentrations. In addition to serving as metabolic precursors for lipid and carbohydrate synthesis, they also act as cognate ligands for two known G protein-coupled receptors (GPCRs), FFAR2 and FFAR3. While there is evidence that these receptors may inhibit the progression of colorectal cancer,...

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Source

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Identifiers

PMID: 29049318
DOI: 10.1371/journal.pone.0186334
PMCID: PMC5648159

Genes

FFAR2
FFAR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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