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Article

Cryptic genetic variation enhances primate L1 retrotransposon survival by enlarging the functional coiled coil sequence space of ORF1p.

PLoS genetics - 1 Aug 2020

Furano Anthony V, Jones Charlie E, Periwal Vipul, Callahan Kathryn E, Walser Jean-Claude, Cook Pamela R

Abstract excerpt

Accounting for continual evolution of deleterious L1 retrotransposon families, which can contain hundreds to thousands of members remains a major issue in mammalian biology. L1 activity generated upwards of 40% of some mammalian genomes, including humans where they remain active, causing genetic defects and rearrangements. L1 encodes a coiled coil-containing protein that is essential for retrotransposition, and...

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Identifiers

PMID: 32797042
DOI: 10.1371/journal.pgen.1008991
PMCID: PMC7449397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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