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Article

Transthyretin interacts with actin regulators in a Drosophila model of familial amyloid polyneuropathy.

Scientific reports - 12 Aug 2020

I Oliveira da Silva Marina, Lopes Carla S, Liz Márcia A

Abstract excerpt

Familial amyloid polyneuropathy (FAP) is a neurodegenerative disorder whose major hallmark is the deposition of mutated transthyretin (TTR) in the form of amyloid fibrils in the peripheral nervous system (PNS). The exposure of PNS axons to extracellular TTR deposits leads to an axonopathy that culminates in neuronal death. However, the molecular mechanisms underlying TTR-induced neurodegeneration are still...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32788615
DOI: 10.1038/s41598-020-70377-4
PMCID: PMC7423984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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