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Article

Misfolded transthyretin causes behavioral changes in a Drosophila model for transthyretin-associated amyloidosis.

The European journal of neuroscience - 1 Aug 2007

Pokrzywa Malgorzata, Dacklin Ingrid, Hultmark Dan, Lundgren Erik

Abstract excerpt

Familial amyloidotic polyneuropathy is an autosomal dominant neurodegenerative disorder caused by accumulation of mutated transthyretin (TTR) amyloid fibrils in different organs and prevalently around peripheral nerves. We have constructed transgenic flies, expressing the clinical amyloidogenic variant TTRL55P and the engineered variant TTR-A (TTRV14N/V16E) as well as the wild-type protein, all in secreted form....

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Source

Identifiers

PMID: 17714186
DOI: 10.1111/j.1460-9568.2007.05728.x

Genes

TTR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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