Article
Modeling familial amyloidotic polyneuropathy (Transthyretin V30M) in Drosophila melanogaster.
Neuro-degenerative diseases - 1 Jan 2009
Berg Ina, Thor Stefan, Hammarström Per
Abstract excerpt
BACKGROUND/AIMS: Transthyretin (TTR) is a prevalent plasma and cerebrospinal fluid protein associated with sporadic and heritable amyloidosis. TTR amyloidosis is linked to a vast number of mutations with varying phenotype, tissue distribution and age of onset. The most prevalent mutation associated with familial amyloidotic polyneuropathy (FAP) is the V30M mutation. Studies of transgenic mouse models of TTR V30M...
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