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Article

HLAs associated with perampanel-induced psychiatric adverse effects in a Korean population.

Scientific reports - 12 Aug 2020

Jang Yoonhyuk, Kim Tae-Joon, Moon Jangsup, Yang Tae-Won, Kim Keun Tae, Park Byeong-Su, Lim Jung-Ah, Jun Jin-Sun, Lee Soon-Tae, Jung Keun-Hwa, Park Kyung-Il, Jung Ki-Young, Chu Kon, Lee Sang Kun

Abstract excerpt

Perampanel (PER) is a new-generation antiepileptic drug that has an occasional but significant shortcoming, psychiatric adverse effects (PAEs). Recently, antiepileptic drug-related adverse reactions, such as skin rash and even PAEs, have been discovered to be correlated with certain human leukocyte antigen (HLA) types. Thus, we aimed to analyze specific HLA alleles as risk factors for PER-PAEs. We prospectively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32788606
DOI: 10.1038/s41598-020-70601-1
PMCID: PMC7423598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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