Article
Pharmacogenetics of antiepileptic drug-induced hypersensitivity.
Pharmacogenomics - 1 Apr 2014
Bloch Katarzyna M, Sills Graeme J, Pirmohamed Munir, Alfirevic Ana
Abstract excerpt
Antiepileptic drugs can induce potentially life-threatening hypersensitivity reactions such as Stevens-Johnson syndrome at a frequency of one in 10,000 to one in 1000 treated patients. There is a considerable cross-reactivity among different antiepileptic drugs but the mechanisms are not known. In this review we have summarized current evidence on antiepileptic drug-induced hypersensitivity reactions and...
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