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Article

Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity.

Physiology (Bethesda, Md.) - 1 Sept 2020

Goldsteen Pien A, Dolga Amalia M, Gosens Reinoud

Abstract excerpt

The peripheral nervous system (PNS) plays crucial roles in physiology and disease. Neuro-effector communication and neuroplasticity of the PNS are poorly studied, since suitable models are lacking. The emergence of human pluripotent stem cells (hPSCs) has great promise to resolve this deficit. hPSC-derived PNS neurons, integrated into organ-on-a-chip systems or organoid cultures, allow co-cultures with cells of...

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Identifiers

PMID: 32783607
DOI: 10.1152/physiol.00010.2020

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