Article
Pancreatic Tumor Microenvironment Factor Promotes Cancer Stemness via SPP1-CD44 Axis.
Gastroenterology - 1 Dec 2021
Nallasamy Palanisamy, Nimmakayala Rama Krishna, Karmakar Saswati, Leon Frank, Seshacharyulu Parthasarathy, Lakshmanan Imayavaramban, Rachagani Satyanarayana, Mallya Kavita, Zhang Chunmeng, Ly Quan P, Myers Molly S, Josh Lindenberger, Grabow Corinn E, Gautam Shailendra K, Kumar Sushil, Lele Subodh M, Jain Maneesh, Batra Surinder K, Ponnusamy Moorthy P
Abstract excerpt
BACKGROUND & AIMS: Tumor-microenvironment factors and cancer stem cells (CSCs) play a critical role in the aggressiveness of pancreatic cancer (PC). However, the degree to which tumor-microenvironment factors promote stemness remains unexplored. Here, we examined whether cancer-associated fibroblasts (CAFs) promote CSC features in PC. METHODS: PC cells were treated long-term (30, 60, and 90 days) with conditioned...
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