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Article

Highly-selective detection of EGFR mutation gene in lung cancer based on surface enhanced Raman spectroscopy and asymmetric PCR.

Journal of pharmaceutical and biomedical analysis - 25 Oct 2020

Guo Ting, Li Weimiao, Qian Lu, Yan Xiaolong, Cui Daxiang, Zhao Jinbo, Ni Haibin, Zhao Xiangwei, Zhang Zhipei, Li Xiaofei, Huang Lijun, Wang Lei

Abstract excerpt

The evaluation of EGFR mutation genes in circulating tumor DNA (ctDNA) in blood sample is key for patients with lung cancer. Surface-enhanced Raman scattering (SERS) has potential for trace detection of DNA or RNA. The detection rate offered by current methods can not meet clinical demand. By combining asymmetric polymerase chain reaction (PCR) and SERS, a highly-selective detection for EGFR mutation genes in...

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Identifiers

PMID: 32777732
DOI: 10.1016/j.jpba.2020.113522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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