Article
TM6SF2 rs58542926 impacts lipid processing in liver and small intestine.
Hepatology (Baltimore, Md.) - 1 May 2017
O'Hare Elizabeth A, Yang Rongze, Yerges-Armstrong Laura M, Sreenivasan Urmila, McFarland Rebecca, Leitch Carmen C, Wilson Meredith H, Narina Shilpa, Gorden Alexis, Ryan Kathy A, Shuldiner Alan R, Farber Steve A, Wood G Craig, Still Christopher D, Gerhard Glenn S, Robishaw Janet D, Sztalryd Carole, Zaghloul Norann A
Abstract excerpt
The transmembrane 6 superfamily member 2 (TM6SF2) loss-of-function variant rs58542926 is a genetic risk factor for nonalcoholic fatty liver disease and progression to fibrosis but is paradoxically associated with lower levels of hepatically derived triglyceride-rich lipoproteins. TM6SF2 is expressed predominantly in liver and small intestine, sites for triglyceride-rich lipoprotein biogenesis and export. In light...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.