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Article

Association between BCL11A, HSB1L-MYB, and XmnI γG-158 (C/T) gene polymorphism and hemoglobin F level in Egyptian sickle cell disease patients.

Annals of hematology - 1 Oct 2020

El-Ghamrawy Mona, Yassa Marianne E, Tousson Angie M S, El-Hady Marwa Abd, Mikhaeil Erini, Mohamed Nada B, Khorshied Mervat Mamdooh

Abstract excerpt

Sickle cell disease (SCD) is a monogenic disease characterized by multisystem morbidity and highly variable clinical course. Inter-individual variability in hemoglobin F (HbF) levels is one of the main modifiers that account for the clinical heterogeneity in SCD. HbF levels are affected by, among other factors, single nucleotide polymorphisms (SNPs) at the BCL11A gene and the HBS1L-MYB intergenic region and Xmn1...

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Share to Anemia, Sickle Cell
Share to Deoxyribonucleases, Type II Site-Specific

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Intergenic

Share to Fetal Hemoglobin

Share to gamma-Globins

Share to Genes, myb

Share to GTP-Binding Proteins

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PMID: 32772141
DOI: 10.1007/s00277-020-04187-z

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Association between BCL11A, HSB1L-MYB, and XmnI γG-158 (C/T) gene polymorphism and hemoglobin F level in Egyptian sickle cell disease patients.PMID 32772141Read ↗

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