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The Impact of XmnI-HBG2, BCL11A and HBS1L-MYB Single Nucleotide Polymorphisms on Hb F Variation of Hematologically Normal Iranian Individuals.

Hemoglobin - 1 Jun 2016

Keyhani Elaheh, Jafari Vesiehsari Mahjoobeh, Talebi Kakroodi Setareh, Darabi Elham, Zamani Fahimeh, Karimlou Masoud, Kamali Koorosh, Neishabury Maryam

Abstract excerpt

The impact of Hb F on severity of sickle cell disease and β-thalassemia (β-thal) is well documented. The XmnI-HBG2, BCL11A and HBS1L-MYB single nucleotide polymorphisms (SNPs) have been introduced as the most important factors causing variation in fetal hemoglobin (Hb F) levels in different population studies. However, the extent of their effect could be population-specific. In this study, multivariate linear...

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Identifiers

PMID: 27117569
DOI: 10.3109/03630269.2016.1160920

Genes

HBG2
MYB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Impact of XmnI-HBG2, BCL11A and HBS1L-MYB Single Nucleotide Polymorphisms on Hb F Variation of Hematologically Normal Iranian Individuals.PMID 27117569Read ↗

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Influence of single nucleotide polymorphisms in the BCL11A and HBS1L-MYB gene on the HbF levels and clinical severity of sickle cell anaemia patientsSemantic proximity Read ↗

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Correlations between Multiple SNPs and HbF Levels in β-Thalassemia Carriers.Semantic proximity Read ↗

The XmnI (G)gamma polymorphism influences hemoglobin F synthesis contrary to BCL11A and HBS1L-MYB SNPs in a cohort of 57 beta-thalassemia intermedia patients.Semantic proximity Read ↗

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