Article
Existence of HbF Enhancer Haplotypes at HBS1L-MYB Intergenic Region in Transfusion-Dependent Saudi β-Thalassemia Patients.
BioMed research international - 1 Jan 2017
Cyrus Cyril, Vatte Chittibabu, Borgio J Francis, Al-Rubaish Abdullah, Chathoth Shahanas, Nasserullah Zaki A, Jarrash Sana Al, Sulaiman Ahmed, Qutub Hatem, Alsaleem Hassan, Alzahrani Alhusain J, Steinberg Martin H, Ali Amein K Al
Abstract excerpt
Background and Objectives. β-Thalassemia and sickle cell disease are genetic disorders characterized by reduced and abnormal β-globin chain production, respectively. The elevation of fetal hemoglobin (HbF) can ameliorate the severity of these disorders. In sickle cell disease patients, the HbF level elevation is associated with three quantitative trait loci (QTLs), BCL11A, HBG2 promoter, and HBS1L-MYB intergenic...
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