APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan.

doi:10.1136/jnnp.2010.209122

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Article

APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan.

Journal of neurology, neurosurgery, and psychiatry - 1 Feb 2011

Wang Pei-Ning, Hong Chen-Jee, Lin Ker-Neng, Liu Hsiu-Chih, Chen Wei-Ta

Abstract excerpt

OBJECTIVE: To evaluate the effect of the apolipoprotein E (APOE) ε4 in the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) in ethnic Chinese people in Taiwan. METHODS: Subjects older than 60 years with normal cognition, MCI or AD were enrolled from the memory clinic from 2000 to 2008. Normal ageing and MCI subjects were evaluated with clinical and neuropsychological examinations...

Topics

Aged
Alzheimer Disease
Apolipoprotein E4
Asian People
Cognition Disorders
DNA
Disease Progression
Executive Function
Female
Follow-Up Studies
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Kaplan-Meier Estimate

Male

Neuropsychological Tests

Regression Analysis

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 20660919
DOI: 10.1136/jnnp.2010.209122

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20660919-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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