Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic.

Nature communications - 9 Jun 2023

Silva Kalinga Pavan T, Sundar Ganesh, Khare Anupama

Abstract excerpt

Antibiotics that have multiple cellular targets theoretically reduce the frequency of resistance evolution, but adaptive trajectories and resistance mechanisms against such antibiotics are understudied. Here we investigate these in methicillin resistant Staphylococcus aureus (MRSA) using experimental evolution upon exposure to delafloxacin (DLX), a novel fluoroquinolone that targets both DNA gyrase and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Antibiotic Resistance in Bacteria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibiotics Pharmacokinetics and Efficacy

Share to Fluoroquinolones

Share to Gene Amplification

Share to Methicillin-Resistant Staphylococcus aureus

Share to Microbial Sensitivity Tests

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 37296157
DOI: 10.1038/s41467-023-38507-4
PMCID: PMC10256781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic.PMID 37296157Read ↗

Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates.Semantic proximity Read ↗

Multidrug evolutionary strategies to reverse antibiotic resistance.Semantic proximity Read ↗

Antibiotic resistance mediated by gene amplificationsSemantic proximity Read ↗

Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance.Semantic proximity Read ↗

Two Classes of DNA Gyrase Inhibitors Elicit Distinct Evolutionary Trajectories Toward Resistance in Gram-Negative PathogensSemantic proximity Read ↗

Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance.Semantic proximity Read ↗

Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens.Semantic proximity Read ↗

Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in Pseudomonas aeruginosaSemantic proximity Read ↗

Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-negative Bacterial PathogensSemantic proximity Read ↗

Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects.Semantic proximity Read ↗

Genetic context drives evolution of divergent antibiotic survival phenotypes in <i>Staphylococcus epidermidis</i>Semantic proximity Read ↗

Genomics of rapid adaptation to antibiotics: convergent evolution and scalable sequence amplification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.