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Article

Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Jan 2018

Bozkurt Süheyla Uyar, Dagcinar A, Tanrikulu B, Comunoglu N, Meydan B C, Ozek M, Oz B

Abstract excerpt

PURPOSE: Pediatric high-grade gliomas (pHGGs) constitute almost 15% of all childhood brain tumors. Recurrent mutations such as H3K27M mutation in H3F3A and HIST1H3B genes encoding histone H3 and its variants were identified in approximately 30% of pediatric glioblastomas. This study aimed to ascertain the morphological and molecular characteristics of pHGGs with H3K27M mutation. METHODS: In total, 61 cases of...

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PMID: 29063957
DOI: 10.1007/s00381-017-3633-5

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ATRX
IDH1
BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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