Article

High-Content, Cell-by-Cell Assessment of HER2 Overexpression and Amplification for Heterogeneity Detection in Breast Cancer

2018-09-17

Abstract excerpt

Immunohistochemistry and fluorescence in situ hybridization are the two standard methods for Human Epidermal Growth Factor Receptor 2 (HER2) assessment. However, they have severe limitations to assess quantitatively intratumoral heterogeneity (ITH) when multiple subclones of tumor cells co-exist. We develop here a high-content, quantitative analysis of breast cancer tissues based on microfluidic experimentation an...

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Literature Corpus work: 4da49616-5891-58ab-bab9-ef8f32df074c
DOI: 10.1101/419499

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